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Hiroshi Aikata Selected Research

Antiviral Agents (Antivirals)

1/2023Hepatitis B Virus (HBV) Upregulates TRAIL-R3 Expression in Hepatocytes Resulting in Escape From Both Cell Apoptosis and Suppression of HBV Replication by TRAIL.
1/2021Comparison of liver disease state progression in patients with eradication of versus persistent infection with hepatitis C virus: Markov chain analysis.
12/2020Real-word efficacy of sofosbuvir, velpatasvir plus ribavirin therapy for chronic hepatitis patients who failed to prior DAA therapy with NS5A-P32 deletion mutated HCV infection.
12/2020PNPLA3 and HLA-DQB1 polymorphisms are associated with hepatocellular carcinoma after hepatitis C virus eradication.
11/2020Impact of viral eradication by direct-acting antivirals on the risk of hepatocellular carcinoma development, prognosis, and portal hypertension in hepatitis C virus-related compensated cirrhosis patients.
4/2020Three Children Treated with Direct-acting Antivirals for Chronic Hepatitis C Virus Genotype 1b Infection.
1/2020Diminished hepatic IFN response following HCV clearance triggers HBV reactivation in coinfection.
7/2019Comparison of intracellular responses between HBV genotype A and C infection in human hepatocyte chimeric mice.
3/2019Real-world efficacy of glecaprevir plus pibrentasvir for chronic hepatitis C patient with previous direct-acting antiviral therapy failures.
1/2019The impact of interferon-free direct-acting antivirals on clinical outcome after curative treatment for hepatitis C virus-associated hepatocellular carcinoma: Comparison with interferon-based therapy.
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Hiroshi Aikata Research Topics

Disease

143Hepatocellular Carcinoma (Hepatoma)
04/2024 - 09/2002
60Neoplasms (Cancer)
02/2024 - 01/2007
46Infections
01/2023 - 04/2009
29Chronic Hepatitis C
01/2021 - 01/2007
26Neoplasm Metastasis (Metastasis)
10/2021 - 01/2007
24Liver Cirrhosis (Hepatic Cirrhosis)
01/2021 - 10/2007
22Fibrosis (Cirrhosis)
02/2024 - 10/2007
20Thrombosis (Thrombus)
06/2023 - 10/2007
13Non-alcoholic Fatty Liver Disease
04/2023 - 03/2014
12Chronic Hepatitis B
01/2021 - 08/2010
12Hepatitis C
09/2020 - 06/2007
10Liver Diseases (Liver Disease)
03/2022 - 11/2011
9Esophageal and Gastric Varices (Esophageal Varices)
01/2021 - 01/2008
8Liver Neoplasms (Liver Cancer)
12/2023 - 05/2009
8Portal Hypertension
04/2023 - 01/2008
8Hepatitis B
01/2023 - 03/2015
8Hepatic Encephalopathy
11/2020 - 03/2011
7Hepatitis
01/2021 - 08/2008
6Disease Progression
04/2020 - 12/2010
5Chronic Hepatitis (Chronic Active Hepatitis)
01/2023 - 03/2017
4Cholangiocarcinoma
01/2022 - 05/2009
4Hemorrhage
01/2021 - 01/2008
4Edema (Dropsy)
02/2020 - 08/2016
4Type 2 Diabetes Mellitus (MODY)
01/2018 - 03/2014
4Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome)
05/2017 - 08/2012
3Carcinogenesis
04/2023 - 01/2016
3Pancreatitis
08/2022 - 10/2014
3Sarcopenia
07/2022 - 03/2019
3Insulin Resistance
03/2022 - 12/2014
3Lymphatic Metastasis
01/2022 - 08/2012
3Liver Failure
02/2021 - 01/2008
3Varicose Veins (Varicose Vein)
11/2020 - 05/2002
3Brain Diseases (Brain Disorder)
08/2019 - 03/2013
3Acute Liver Failure (Fulminant Hepatic Failure)
12/2017 - 08/2014
3Anemia
06/2017 - 05/2013
3Carcinoma (Carcinomatosis)
06/2015 - 07/2011

Drug/Important Bio-Agent (IBA)

41InterferonsIBA
01/2021 - 10/2007
34Sorafenib (BAY 43-9006)FDA Link
09/2023 - 01/2012
27lenvatinibIBA
04/2024 - 01/2019
23Antiviral Agents (Antivirals)IBA
01/2023 - 05/2012
21Ribavirin (Virazole)FDA LinkGeneric
12/2020 - 01/2007
14daclatasvirIBA
01/2020 - 01/2014
13asunaprevirIBA
01/2020 - 01/2015
11Cisplatin (Platino)FDA LinkGeneric
04/2024 - 09/2002
10Bevacizumab (Avastin)FDA Link
03/2024 - 08/2021
10atezolizumabIBA
03/2024 - 08/2021
10Biomarkers (Surrogate Marker)IBA
02/2024 - 01/2016
10RNA (Ribonucleic Acid)IBA
01/2023 - 06/2008
10Fluorouracil (Carac)FDA LinkGeneric
12/2018 - 10/2007
8Hepatitis B Surface Antigens (HBsAg)FDA Link
04/2023 - 01/2017
8AntigensIBA
01/2021 - 10/2015
7Proteins (Proteins, Gene)FDA Link
08/2023 - 07/2016
7Capsules (Microcapsules)IBA
07/2022 - 05/2013
7Glucose (Dextrose)FDA LinkGeneric
03/2022 - 03/2014
7DNA (Deoxyribonucleic Acid)IBA
11/2021 - 09/2015
6Alanine Transaminase (SGPT)IBA
04/2024 - 03/2014
6NucleotidesIBA
01/2023 - 01/2017
6SofosbuvirIBA
12/2020 - 04/2017
6Interferon-alpha (Interferon Alfa)IBA
04/2009 - 01/2007
5Aspartate Aminotransferases (Aspartate Transaminase)IBA
04/2024 - 12/2014
5Hemoglobins (Hemoglobin)IBA
04/2023 - 05/2015
5telaprevirIBA
06/2016 - 10/2014
5Ethiodized Oil (Ethiodol)FDA Link
07/2013 - 09/2002
4alpha-Fetoproteins (alpha-Fetoprotein)IBA
11/2023 - 05/2016
4BilirubinIBA
08/2023 - 12/2017
4AlbuminsIBA
08/2023 - 07/2016
4Tumor Biomarkers (Tumor Markers)IBA
01/2022 - 04/2015
4EnzymesIBA
02/2021 - 06/2008
4Immunoglobulins (Immunoglobulin)IBA
01/2021 - 10/2015
4regorafenibIBA
01/2021 - 09/2018
4Fetal Proteins (Fetoprotein)IBA
11/2020 - 01/2012
4ChemokinesIBA
03/2020 - 01/2016
4CytokinesIBA
01/2020 - 01/2016
4Urokinase-Type Plasminogen Activator (Urokinase)FDA Link
05/2017 - 08/2012
4SimeprevirIBA
03/2017 - 06/2016
3Serum AlbuminIBA
08/2023 - 11/2011
3Complementary DNA (cDNA)IBA
01/2023 - 05/2017
3Immune Checkpoint InhibitorsIBA
11/2022 - 10/2020
3pembrolizumabIBA
08/2022 - 07/2020
3Circulating Tumor DNAIBA
06/2021 - 09/2015
3Prothrombin (Factor II)IBA
01/2021 - 12/2014
3ChromatinIBA
01/2021 - 05/2018
3Immunoglobulin G (IgG)IBA
01/2021 - 06/2008
3Tyrosine Kinase InhibitorsIBA
01/2021 - 01/2020
3Protease Inhibitors (Protease Inhibitor)IBA
04/2020 - 11/2014
3AmmoniaIBA
08/2019 - 12/2018
3NucleosidesIBA
01/2019 - 01/2018
3ledipasvirIBA
12/2018 - 04/2017
3Zoledronic Acid (Zometa)FDA Link
09/2017 - 12/2010
3Hyaluronic Acid (Hyaluronan)IBA
07/2016 - 01/2016

Therapy/Procedure

100Therapeutics
03/2024 - 01/2007
33Drug Therapy (Chemotherapy)
04/2024 - 04/2008
18Radiotherapy
06/2023 - 12/2010
18Liver Transplantation
01/2023 - 06/2007
15Hepatectomy
12/2023 - 08/2012
6Surgical Portasystemic Shunt (Portosystemic Shunt)
08/2019 - 03/2011
5Radiofrequency Ablation
01/2020 - 03/2010
4Splenectomy
04/2023 - 06/2007
4Sclerotherapy
01/2021 - 01/2009
3Conformal Radiotherapy
06/2015 - 01/2009